发表论文（一）Chief Papers-1

发表论文 Chief Papers

1. Jianhui Wu, Han Yan, Xin Su, Li Xu, Zuyue Sun. To increase SOP compliance rate through combining Chinese traditional culture with GLP guideline. 4th global QA conference & 30th SOA annual meeting. 6-11, April 2014, Las Vegas, Nevada, USA. p. 69.

2. Xin Su, Li Xu, Han Yan, Jianhui Wu, Zuyue Sun. Quality assurance for management of test and comtrol substances in preclinical safety evaluation. 4th global QA conference & 30th SOA annual meeting. 6-11, April 2014, Las Vegas, Nevada, USA. p. 103.

3. Shengsheng Zhu, Xiang Meng, Xin Su, YongweiLuo, Zuyue Sun. Development and validation of a stability-indicating high performance liquid chromatographic (HPLC)method for the determination of related substances of micafungin sodium in drugsubstance. International journal of molecular sciences 2013, 14, 21202-21214.（IF = 2.464）.

4. Xiang-yun Liu, Li Xu, Lei Li, Yi Cheng, Yue Shao, Jian-yan Yan, Zu-yue Sun. Gene expression of mitotic reorientation on rat prostate epithelial cells exposed to subchronic testosterone. Toxicology Letters 2013, 221S, 28:S235.

5. Hong SUN, Ting ZHANG,Xin SU, Xiang MENG, Zu-yue SUN. A Newly-developed RP-HPLC Method for the Analysis of Epristeride in Rat Serum and its Validation. Latin American Journal of Pharmacy 2012, 31(8): 1132-7.（IF = 0.244）

6. H. Sun, T. Zhang, B. Gui, L.-W. Song, L. Li, Q. Pan, R.-F. Yang, Y. Shao, X.-Y. Liu, Z.-Y. Sun. Establishment of prostate cancer in cynomolgus macaque animal model byorthotropic inoculation of PC-3 cancer cells in situ. Eur. J. Oncol. 2012, 17(4): 189-203.（IF = 0.75）

7. Jian-hui Wu, Xin Su, Han Yan, Xiang Meng, Qi Pan, Zu-yue Sun. Relationship between low-dose bishpenol A and benign hyper;lasia prostate. The 8th congress of Toxicology in Developing countries (8CTDC), september 10-13, 2012: 155.

8. Xiang Meng, Qi Pan, Jian-hui Wu, Li Zhou, Ying Li, Li Xu, Zu-yue Sun. Study on the toxicokinetics of Scutellarin in beagle dogs. The 8th congress of Toxicology in Developing countries (8CTDC), september 10-13, 2012: 75.

9. R F Yang, Y Gao, X Liu, Y Li, Z Y Sun. Toxicity of docetaxel-loaded solid lipid nanoparticles (DSNs) and Taxotere – A comparative in vivo study. Toxicology Letters 2011, S60-S179.

10. Jianhui Wu, Xiu-Rong Jiang, Gui-Ming Liu, Xiang-Yun Liu, Gui-Lin He, Zu-Yue Sun. Oral exposure to low-dose bisphenol A aggravates testosterone-induced benign hyperplasia prostate in rats. Toxicology and Indusrial Health 2011, 27（9）：810-819.

11、 Gao Y, Yang R, Zhang Z, Chen L, Sun Z, Li Y. Solid lipid nanoparticles reduce systemic toxicity of docetaxel: Performance and mechanism in animal. Nanotoxicology. 2011，5（4）：636-649.

12. Liu Xiang-Yun, Xu Ying-Wen, Xie Chen-Jing, Wang Jiu-Jiu, Pan Qi, Gui Bo, Sun Zu-Yue. Possible mechanism of benign prostatic hyperplasia induced by androgen-estrogen ratio in castrated rats. Indian J Phamacol 2010:42(5):312-317.

13. Sun Zu-Yue，Feng Jie，Qi Xiao-Dong，Wu Hong Yan，Zheng Wei-Jun，Tu Zeng-Hong． Reversible long-term toxicity of epristeride on Beagle Dogs．Toxicol Appl Pharm 1999；154：145-152．

14. SUN Zu-Yue，WU Hong-Yan，WANG Mei-Ying，TU Zeng-Hong．The mechanism of epristeride against benign prostatic hyperplasia．Euro J Pharmacol．1999，371（2-3）：227-233．

15. SUN Zu-Yue，ZHENG Wei-Jun，FENG Iie，TU Zeng-Hong． A convenient and rapid method to study enzymatics of steroid 5α-reductase inhibitors．Indian J Pharmacol  l998，30（4）：257-262．

16. SUN Zu-Yue，XIE Hong，ZHENG Wei-Jun，TU Zeng-Hong．Effects of finasteride andepristeride on steroid 5α-reductase kinetics—A Comparative in vitro study．Indian J Pharmacol 1999，31（2）：120-123．

17. SUN Zu-Yue, TU Zeng-Hong. A novel in vitro model to screen steroid 5α-reductase inhibitors against benig prostatic hyperplasia. Methods Find Exp Clin Pharmacol 1998；20（4）:283-287.

18. Jian-Hui Wu, Zu-Yue Sun. A repid screening model of steroid 5 alpha-reducase inhibitor in vitro. Asian J  Androl 2009; 11(5 Suppl):57-58.

19. Jian-Hui Wu, Jiu-Jiu Wang, Rong-Fu Yang, Yin-Wen Xu, Chen-Jing Xie, Xiu-Rong Jiang, Xiang-Yun Liu, Gui-Lin He, Gui-Ming Liu, Zu-Yue Sun. Low dose effects of bisphenol-A on the male reproductive system in adult rats. Asian J Androl 2009; 11(5 Suppl):106.

20. Xiang-yun LIU, dong-mei LI, Xiao-fang ZHANG, Jian-hui WU, Zu-yue SUN. Mitosis orientation in prostate epithelial cells changed by endocrine effect. Acta Pharmacol Sin 2008, 29 （2）: 226-229.

21. Zuyue Sun, Xiang-yun Liu, Dong-mei Li, Shu-wu Xie, Lin Cao. Mitosis orientation alterde for androge in the prostate epithelia. ICT XI International Congress of Toxicology July 2007: Montreal, Canada: P 54.

22. Yan ZHU, Xiao-yan QIU, Jian-hui WU, Gui-ming LIU, Gui-lin HE, Xiu-rong JIANG, Zu-yue SUN, Lin Cao. Effects of gestrinone on uterine leionmyoma and expression of c-Src in a guinea pig model. Acta Pharmacol Sin 2007, 28（5）:685-694.

23. Shu-Wu Xie, Zhi-Ling Li, Lei Wang, Zhi-fang Zhao, Xiu Rong Jiang, Li Ma, Dong-Mei Li, Xiang-Yun Liu, Zu-Yue Sun, Lin Cao. An animal model of male sterility related to epididymis caused by dutasteride: the possible role for screening fertility genes about fertility and male contraception. Asian J androl 2006, 8（5 Wuppl）: 85-86.

24. Zu-Yue Sun, Jian-Hong Chu, Zhi-Ling Li, Xiang-Yun Liu, Xiao-Fang Zhang,  Jian-Hui Wu, Yan Zhu, Lin Cao. The toxicological study on PC-3M cells attacking nude mice. Toxicology Letters. 2006, 164S: S113-114.

25. J.H.Wu, Z.Y.Sun, L.Cao. In vitro effects of Epristeride on sperm in rats, dogs and man. Archives of Andrology. 2006, 52: 191-195.

26. Jian-hong Chu, Zu-yue Sun, Xue Lian Meng, Jian Hui Wu, Gui Lin He, Gui Ming Liu and Xiu Rong Jiang. Differential metastasis-associated gene analysis of prostate carcinoma cells derived from primary tumor and spontaneous lymphatic metasis in nude mice with orthotopic implantation of PC-3M cells. Cancer Letters 2006, 233（1）: 79-88.

27. Sun Zu-Yue, Zhu Yan, Wu Jian-Hui, Zhong En-Hong, He Gui-Lin, Liu Gui-Ming. Reproductive toxicological study on epristeride. Toxicol Appl Pharm 2004；197: 354.

28. Zhu Shuomin, Wang Aihong, Xu Zude, Sun Zuyue, Xia Zhaolin. DNA and liver dell damages and expressions of P53 and DNA damage repair enzymes in rats exposed to VCM. Toxicol Appl Pharm  2004；197: 328.

29. Zhu Shuomin, Wang Aihong, Wu Jianghui, Sun Zuyue, liu Guiming, Xia Zhaolin. DNA damages of liver cells and expressions of DNA damage repair genes in rats exposed to VCM. Toxicol Appl Pharm  2004，197: 179.

30. Jianhui WU, Hong SUN, Han YAN, Xin SU, Qi PAN, Jiujiu WANG, Zuyue SUN. Proliferation Effect of Low Dose Bisphenol A on Ventral Prostate and Relative differential Gene

Analysis in Adult Rats. 第十三届中国科协年会. Tianjin. China. Sep 20-22, 2011，131-135.

31、 刘絮，周莉，孙祖越. 药物的雄性生殖毒性表现及其机制研究进展. 中国新药杂志 2014，23（11）：1290-1294.
31. Liu Xu, Zhou Li, Sun Zuyue. Progress in the study of male reproductive toxicity and its mechanism. Chinese Journal of New Drugs 2014，23（11）：1290-1294.

32、 陈颖，李莹，管隽，王忠辉，贾玉玲，周莉，孙祖越. 标准化Ames波动试验最佳条件优选研究. 癌变.畸变.突变  2014，26（3）：199-376.
32. Chen Yin, Li Ying, Guanjun, Wang Zhonghui, Jia Yuling, Zhou Li, Sun Zuyue. Study on the standardizaition of optimal condition of Ames fluctuation test. Carcinogenesis, Teratogenesis, mutagenesis 2014，26（3）：199-376.

33、 孙祖越，周莉，吴建辉. 试论药物非临床生殖毒性试验中的真实性、规范性、科学性和创新性. 中国药理学通报 2014，30（5）：597-604.
33. Sun Zuyue，Zhou Li, Wu Jianhui. Discussion on the authenticity, normative, scientific and innovative in non-clinical reproductive toxicity test of drug. Communication of Chinese Toxicology 2014，30（5）：597-604.

34、 邵悦，李雷，崇立明，许丽，桂博，刘向云，周莉，孙祖越. 两种啤酒花浸膏对雄性小鼠生殖毒性的研究. 生殖与避孕 2014，34（5）：354-359.
34. Shao Yue, Li Lei, Chong Liming, Xu Li, Gui Bo, Liu Xiangyun, Zhou Li, Sun Zuyue. Study on reproductive toxicity of two in male mice. Reproduction&contraception 2014，34（5）：354-359.

35、 陈颖，姜娟，杨阳，李莹，周莉，孙祖越. Ames试验假阳性的判断方法. 生物技术通讯 2014，25（2）：242-244.
35. Chen Ying, Jiang Juan，Yang Yang, Li Ying, Zhou Li, Sun Zuyue. Method study on determining the false positive of Ames test. Letters in Biotechnology 2014，25（2）：242-244.

36、 谢琛静，徐斯翀，潘琦，周莉，孙祖越. GLP机构档案室的建立和管理与科研档案管理之比较 现代生物医学进展 2014，14（14）：2763-2768.
36. Xie Chenjing, Xu Sicong，Pan Qi, Zhou Li, Sun Zuyue. Comparison of establishment and management of GLP archives with management of scientific research. Progress in Modern biomedicine 2014，14（14）：2763-2768.

37、 骆永伟，杨春雷，王忠辉，王永，王蓉，姜娟，闫晗，孙祖越. 注射用灯盏花素大鼠和豚鼠免疫毒性差异性研究. 实验动物与比较医学 2014，34（1）：25-28.
37. Luo Yongwei, Yang Cunlei, Wang Zhonghui, Wang Yong, Wang Rong, Jiang Juan, Yan Han, Sun Zuyue. Study on the difference of immunotoxicity of erigeron injection in rats and guinea pig. Laboratory Animal and Comparative Medicine 2014，34（1）：25-28.

38、 周莉，骆永伟，王永，王蓉，刘向云，桂博，贾玉玲，孙祖越. 雌激素诱导SD大鼠前列腺炎与内环境改变的关系. 中国比较医学杂志 2014，24（2）：33-37，2.
38. Zhou Li, Luo Yongwei, Wang Yong, Wang Rong, Liu Xiangyun, Gui Bo, Jia Yuling, Sun Zuyue. Relationship between prostatitis induced by estrogen in SD rats and changes of internal environment Chinese Journal of Comparative Medicine 2014，24（2）：33-37，2.

39、 黄冬研，吴建辉，孙祖越. 前列腺增生药物评价模型分类及特点比较. 中华男科学杂志 2014，20（2）：181-185. 
39. Huang Dongyan, Wu Jianhui, Sun Zuyue. Comparison of model classification of prostatic hyperplasia and characteristics of drugs.Chinese Journal of Andrology 2014，20（2）：181-185.

40、 刘向云，王永，李雷，许丽，苏欣，桂博，周莉，孙祖越. 注射用灯盏花素对大鼠和犬的毒性病理学比较. 中国药理学与毒理学杂志 2013，27（6）：1000-1006.
40. LIU Xiang-yun, WANG Yong, LI lei, XU Li, SU Xin, GUI Bo, ZHOU Li, SUN Zu-yue. Comparison of toxicity pathology of breviscapine in SD rats and Beagle dogs. Chin J Pharmacol Toxicol 2013, 27(6): 1000-1006.

41、 朱圣生，吴建辉，孙祖越. 良性前列腺增生发病机制的研究进展. 毒理学杂志 2013，27（5）：387-390.
41. ZHU Sheng-sheng, WU Jian-hui, SUN Zu-yue. Research progress on the pathogenesis of benign prostatic hyperplasia. J Toxicol 2013，27（5）：387-390.

42、 孟祥，杨春雷，李莹，潘琦，许丽，徐斯翀，周莉，孙祖越. 注射用灯盏花素对Beagle犬静脉给药的毒代动力学研究. 毒理学杂志 2013，27（5）：345-349，352.
42. Meng Xiang, Yang Chun-lei, Li Ying, Pan Qi, Xu Si-Chong, Xu Li, Zhou Li, Sun Zu-yue. Toxicokinetics of scutellarin in Beagle dogs. J Toxicol 2013，27（5）：345-349，352.

43、 陈颖，李莹，马爱翠，许丽，潘琦，刘向云，周莉，孙祖越. 染色体畸变试验中常见受试物溶剂对CHL细胞毒性比较研究. 癌变?畸变?突变  2013，25（5）：373-376.
43. CHEN Ying, LI Ying, MA Ai-cui, XU Li, PAN Qi, LIU Xiang-yun, ZHOU L i, SUN Zu-yue. Comparetive study on different solvent toxicity on CHL cells in chromosome aberration test. Carcinogenesis,Teratogenesis & Mutagenesis 2013，25（5）：373-376.

44、 张婷，李雷，王忠辉，严建燕，潘琦，刘向云，孙祖越. 多柔比星对体外培养小鼠腔前卵泡发育的影响. 癌变?畸变?突变  2013，25（5）：360-364，368.
44. ZHANG Ting, LI Lei, WANG Zhong-hui, YAN Jian-yan, PAN Oi, LIU Xiang-yun, SUN Zu-yue. Effect of doxorubicin on cultured preantral follicle development in mice. Carcinogenesis,Teratogenesis & Mutagenesis 2013，25（5）：360-364，368.

45、 许丽，苏欣，潘琦，邵悦，刘向云，孙祖越. 大鼠、犬和食蟹猴血液学和血清生化指标正常参考的测定. 实验动物与比较医学 2013，33（4）：315-318.
45. Xu Li，Su Xin，Pan Qi，Shao Yue，Liu Xiangyun，Sun Zuyue. Determination of normal reference data of hematological and serum biochemical indexes in rats, dogs and cynomolgus monkeys. Laboratory Animal and Comparative Medicine  2013，33（4）：315-318.

46、 潘琦，许丽，孟祥，李莹，闫晗，桂博，周莉. 孙祖越. 头孢他美钠毒代动力学检测方法学研究. 毒理学杂志 2013，27（3）：227-229.
46. Pan Qi, Xu Li, Xu Si-Chong, Yan Han, Gui Bo, Meng Xiang, Sun Zu-Yue. Study on determination of cefetamet for toxicokinetics. J Toxicol 2013，27（3）：227-229.

47、 李莹，孟祥，周莉，潘琦，桂博，骆永伟，刘向云，孙祖越. 灯盏花素两种血药浓度检测方法比较学研究. 生物技术通讯 2013，24（4）：532-535.
47. LI Ying, MENG Xiang, ZHOU Li, PAN Qi, GUI Bo, LUO Yong-wei, LIU Xiang-yun, SUN Zu-yue. Comparative studies on two assay methods for scutellarin. Letters in Biotechnology 2013，24（4）：532-535.

48、 贾玉玲，周莉，孙祖越. 前列腺炎药理实验方法研究进展. 生物技术通讯 2013，24（4）：579-583.
48. JIA Yu-Ling, ZHOU Li, SUN Zu-Yue. Advance in Methods of Pharmacological Experiments of Prostatitis. Letters in Biotechnology 2013，24（4）：579-583.

49、 周莉，王永，王蓉，许丽，骆永伟，王华，孙祖越. 生育力与早期胚胎发育毒性试验中雄性大鼠阳性模型的建立. 癌变?畸变?突变  2013，25（4）：311-315.
49. ZHOU Li, WANG Yong, WANG Rong, XU Li, Luo Yong-wei, WANG hua, SUN Zu-yue. Positive modeling study on fertility and early embryo developmental toxicityin SD male rat. Carcinogenesis,Teratogenesis & Mutagenesis 2013，25（4）：311-315.

50、 周莉，姜娟，陈颖，王永，崇立明，骆永伟，王华，孙祖越. 环磷酰胺不同给药方式对孕兔胎仔致畸作用的比较. 中国新药杂志 2013，22（13）：1505-1509，1537.
50. ZHOU Li, JIANG Juan, CHEN Ying, WANG Yong, CHONG Li-ming, LUO Yong-wei, WANG Hua, SUN Zu-yue. Comparison teratogenic effect of administration method of cyclophosphamide in rabbit fetuses. Chinese Journal of New Drugs 2013，22（13）：1505-1509，1537.

51、 李雷，严建燕，苏欣，邵悦，程熠，周莉，刘向云，孙祖越. 大鼠睾丸组织固定法的优选研究. 中国比较医学杂志 2013，23（6）：20-23.
51. LI Lei, YAN Jian-yan, SU Xin, SHAO Yue, CHENG Yi, ZHOU Li, ZHOU Li, LIU Xiang-yun, SUN Zu-yue. Welection of optimal fixative for preservation of rat testis. Chinese Journal of Comparative Medicine 2013，23（6）：20-23.

52、 吴建辉，徐斯翀，潘琦，苏欣，闫晗，李雷，邵悦，孙祖越. 自发性及睾酮诱导犬前列腺增生模型的比较. 中国实验动物学报 2013，21（3）：21-26.
52. WU Jian-hui, XU Si-chong, PAN Qi, SU Xin, YAN Han, LI Lei, SHAO Yue, SUN Zu-yue. Comparison of spontaneous and testosterone-induced benign prostatic hyperplasia in dogs. Acta Laboratorium Animals Scientia Sinica 2013，21（3）：21-26.

53、 吴建辉，孙祖越. 酶标仪法5a-还原酶抑制剂体外筛选模型的建立. 中华男科学杂志 2013，19（6）：483-486.
53. WU Jian-hui, SUN Zu-yue. Established of an in vitro screening model for steroid 5 alph-reductase inhibitors with the microplate reader. National Journal of Andrology 2013，19（6）：483-486.

54、 贾玉玲，周莉，孙祖越. 前列腺炎发生机制的研究进展. 实验医学杂志 2013，29（5增刊）：317-320.
54. JIA Yu-ling，ZHOU Li，SUN Zu-yue. Research progress on pathogenesis of prostatitis. The Journal of Practical Medicine 2013，29（5 plus）：317-320.

55、 周莉，姜娟，王永，陈颖，许丽，崇立明，闫晗，王华，孙祖越. 环磷酰胺对新西兰兔胚胎-胎仔发育的毒性作用研究. 药物不良反应杂志 2013，15（2）：87-92.
55. ZHOU Li, JIANG Juan, WANG Yong, XU Li, CHEN Ying, CHONG Li-ming, YAN Han, WANG Hua, SUN Zu-yue. Effects of cyclophoshpamide on embryo-fetal developmental toxicity test with New Zealand rabbits. Adverse Drug Reactions Journal 2013, 15（2）：87-92.

56、 孙祖越，周莉，闫晗. 非临床生殖毒性试验方案设计时应关注的具体问题. 中国毒理学通讯 2013，17（1）：1-6.
56. SUN Zu-yue, ZHOU Li, YAN Han. Specific issues should be focused in design of non-clinical reproductive toxicity study. Communication of Chinese Toxicology 2013，17(1)：1-6.

57、 张婷，程熠，王永，孙祖越. 外源化学物的雌性生殖毒性研究进展. 癌变?畸变?突变  2013，25（2）：155-158.
57. Zhang ting, Chen ye, Wang yong, Sun zuyue. Progress of female reproductive toxicological study on Exogenous chemicals. Carcinogenesis,Teratogenesis & Mutagenesis 2013，25（2）：155-158.

58、 朱圣生，刘向云，孙祖越. 前列腺特异性抗原衍生体及前列腺癌高特异性生物标志研究现状. 中国药理学与毒理学杂志 2013，27（1）：114-118.
58. ZHU Sheng-sheng, LIU Xiang-yun, SUN Zu-Yue. Effects of estradiol on prostate hypeplasia in castrated rats Progress in prostate specific antigen derivatives and biomarkers with high specificity for prostate cancer. Chin J Pharmacol Toxicol 2013, 27(1): 114-118.

59、 谢琛静，刘向云，桂博，崇立明，许丽，潘琦，周莉，孙祖越. 131Ⅰ-单克隆抗体对人卵巢癌细胞株OC-3-VGH裸鼠皮下移植瘤的抑制作用. 癌变.畸变.突变  2013，25（1）：13-17.
59. XIE Chen-jing, LIU Xiang-yun, GUI Bo, CHONG Li-ming, XU Li, ZHOU Li, SUN Zu-yue. Inhibitory effect of 131I-monoclonal antibody on subcutaneously transplanted human ovarian cancer cell line OC-3-VGH tumor. Carcinogenesis,Teratogenesis & Mutagenesis 2013，25（1）：13-17.

60、 王华. 鸡球虫病免疫防制技术的研究. 中国动物保健 2012，14（9）：32-33.
60. Wang Hua. Study on the immunological control of coccidiosis. China Animal Health 2012，14（9）：32-33.