研究项目（二）study projects-2

第二部分：药效学研究
2. PHARMCOLOGY  STUDIES

一、生殖药理学研究
Reproductive Pharmacology

1、SHR145594兔灌胃治疗子宫内膜异位药效学筛选试验
Pharmacodynamic screening test of the treatment of SHR145594 on endometriosis by intragastric administration in rabbits

2、XZP-5849项目BPH及ED药效试验开发研究
Pharmacodynamic study on XZP-5849 against BPH and ED

3、滋肾育胎丸大鼠灌胃治疗因卵巢功能不全导致不孕的药效学试验
Pharmacodynamic study of Zishen Yutai pills on the treatment of infertile rats due to ovarian dysfunction by intragastric administration.

4、滋肾育胎丸大鼠灌胃治疗因卵巢早衰导致不孕的药效学试验
Pharmacodynamic study of Zishen Yutai pills on the treatment of infertile rats due to premature ovarian failure by intragastric administration.

5、雄地那非体外抑制磷酸二酯酶（PDE）药效学试验
Pharmacodynamic study on inhibition of PDEs by Xiongdinafei in vitro

6、灌胃雄地那非对去势大鼠的壮阳作用药效学试验
Pharmacodynamic study on Strengthening yang activity of Xiongdinafei by intragastric administration in neutered rats

7、灌胃雄地那非对兔的壮阳作用药效学试验
Pharmacodynamic study on Strengthening yang activity of Xiongdinafei by intragastric administration in rabbits

8、大鼠灌胃复方坦洛新非那雄胺治疗前列腺增生症筛方试验
Study on screening compound tamsulosin and finasteride treating BPH by intragastric administration in SD rats

9、大鼠灌胃复方坦洛新非那雄胺治疗前列腺增生症药效学试验
Pharmacodynamic study on compound tamsulosin and finasteride treating BPH by intragastric administration in SD rats

10、老年犬灌胃复方坦洛新非那雄胺治疗前列腺增生症药效学试验
Pharmacodynamic study on compound tamsulosin and finasteride treating BPH by intragastric administration in old Beagle dogs

11、治疗生殖系统肿瘤多肽偶联抗癌小分子靶向药物的偶联及其结构鉴定
Conjugate coupling and structural identification of polypeptide to targeted anticancer small molecules for treating cancer of reproductive system

12、治疗生殖系统肿瘤多肽偶联抗癌小分子靶向药物的药学研究
Pharmaceutical research on conjugate coupling of polypeptide to targeted anticancer small molecules for treating cancer of reproductive system

13、治疗生殖系统肿瘤多肽偶联抗癌小分子靶向药物的体内外靶向性研究
Targeting study on conjugate coupling of polypeptide to targeted anticancer small molecules for treating cancer of reproductive system in vivo and in vitro

14、治疗生殖系统肿瘤多肽偶联抗癌小分子靶向药物的药效学研究
Pharmacodynamic study on conjugate coupling of polypeptide to targeted anticancer small molecules for treating cancer of reproductive system

15、滋肾育胎丸大鼠灌胃抗弱精或少精症有效性试验
Study on the efficiency of Zishengyutai Pill treating anti-asthenospermia and anti-oligospermia

16、灌胃SNG-1153对荷瘤（PC-3）裸鼠抑瘤药效学研究
Pharmacodynamic study on the antitumor activity of SNG-1153 in the tumor-bearing (PC-3) nude mice

17、AT-101治疗大鼠子宫内膜异位初步药效学研究
Primary pharmacodynamic developmental research of AT101 on the treatment of rats with endometriosis

18、植物提取物治疗大鼠子宫内膜异位初步药效学开发研究
Primary pharmacodynamic developmental research of plant extracts on the treatment of rats with endometriosis

19.新化合物体外给药对Beagle犬输尿管舒张力影响研究
Study on the effects of new compounds on the relaxation of urethra of Beagle dogs in vitro

20.JH10系列提取物局部给药抗SD大鼠阴道炎及宫颈炎有效性研究
Study on Validity of JH10 series extracts against vaginitis and cervicitis by local injection in SD rats

21.大火草浸膏抗SD大鼠慢性前列腺炎药效学研究
The pharmacodynamic study of Dalian Chinese herbs against Chronic Prostatitis in SD rats

22.建立并完善丙酸睾丸素引起大白鼠前列腺增生法
Establishing and perfecting the method of BPH induced by Testosterone Propionate in rats

23.建立并完善老年犬自发性前列腺增生模型
Establishing and perfecting the model of spontaneously BPH in aged dogs

24.建立并完善丙睾法诱导Beagle犬前列腺增生模型
Establishing and perfecting the model of BPH induced by Testosterone Propionate in Beagle dogs

25.建立并完善甾体5α-还原酶抑制剂体外筛选模型
Establishing and perfecting the model of screening steroid 5α-reductase inhibitors in vitro

26.建立并完善人良性前列腺增生组织原代培养细胞体外筛选模型
Establishing and perfecting the model of screening primary culture cell from tissue of human BPH in vitro

27.建立并完善4种细胞（PC-3、DU145、LNCaP和CWR22Rv1）的裸鼠前列腺癌原位模型
Establishing and perfecting the orthotopic model of the 4 kinds of cells (PC-3, DU145, LNCaP and CWR22Rv1) transplanted prostate cancer in nude mice

28.建立并完善PC-3M细胞的前列腺癌转移模型
Establishing and perfecting the prostate cancer metastatic mode bearing PC-3M cells

29.建立并完善5种细胞（PC-3、PC-3M、DU145、LNCaP和CWR22Rv1）的前列腺癌体外筛药模型
Establishing and perfecting the model of screening for the drug against prostate cancer of 5 cells(PC-3、PC-3M、DU145、LNCaP和CWR22Rv1) in vitro

30.建立并完善前列腺癌细胞（PC-3M）体外浸润筛药模型
Establishing and perfecting the invasive model of prostate cancer(PC-3M)

31.建立并完善前列腺组织蛋白结合免疫佐剂法诱导的大鼠免疫性前列腺炎模型
Establishing and perfecting the immune prostatitis model induced by combination of prostate tissue protein and immunoadjuvant in rats

32.建立并完善雌激素诱导的大鼠前列腺炎模型
Establishing and perfecting the prostatitis model induced by estrogen in rats

33.建立并完善化学诱导的大鼠前列腺炎模型
Establishing and perfecting the prostatitis model induced by chemical reagents in rats

34.建立并完善细菌脂多糖诱导大鼠前列腺腺体上皮细胞的前列腺炎模型
Establishing and perfecting the prostatitis model of rat epithelial cells of prostate gland induced by lipopolysaccharide

35.建立并完善过敏异体蛋白（蛇毒）诱导大鼠前列腺腺体上皮细胞的前列腺炎模型
Establishing and perfecting the prostatitis model of rat epithelial cells of prostate gland induced by allergic allogenic protein

36.类雌激素样物质对前列腺增生作用的研究
Study on the effects of estrogen-like matters on prostatic hyperplasia

37.雄激素引发前列腺上皮细胞有丝分裂方向改变的机制探讨
Mechanism exploring of mitosis orientation in prostate epithelial cells changed by androgen

38.BPA雌激素活性测定试验
Activity Measurement of BPA estrogen

39.BPA对SD大鼠前列腺增生模型作用研究
Study on effects of BPA on the model of hyperplasia of prostate in SD rats

40.BPA对成年SD大鼠前列腺作用研究
Study on effects of BPA on the prostate gland of adult SD rats

41.药物IC-163（羟可拉定）对荷瘤（PC-3）裸鼠药效学研究
Pharmacodynamic Study on IC-163 in nude mice bearing cancer (PC-3)

42.补肾益气调控SOCS基因表达对母胎界面Th2细胞分化的诱导
Effect of Chinese Herbs Bu-Shen of SOCS Genes Expression in Associated with Th2 differentiation in Maternal-fetal Interface

43.莫达非尼抗雄性大鼠不育症模型的药效学试验
Pharmacodynamic test of modafinil against infertility in male rats

44.消避灵阴道栓体外杀精子药效学试验
Pharmacodynamic test of Xiaobiling pessary for killing sperm in vitro

45.雌、雄激素引发前列腺增生的机制研究
Study on the mechanism of prostatic hyperplasia induced by estrogen, androgen

46.药物诱导大鼠附睾不育模型的建立及其作用机理研究
Study on establishment of the epididymis infertility model induced by drugs in rats and its action mechanism

47.前列腺癌裸鼠模型的建立及其应用
Establishment of the nude mice model bearing with the prostate cancer and its application

48.前列腺炎的动物模型建立及机制探讨
Establishment of prostatitis animal model and its mechanisms

49.IC-162（阿可拉定）对荷瘤（PC-3）裸鼠药效学研究
Pharmacodynamic Study on IC-162 in nude mice bearing cancer (PC-3)

50.哈乐类化合物对丙酸睾丸酮诱发的前列腺增生药效学初步研究
Preliminary pharmacodynamic study on effect of harnal compounds on hyperplasia of prostate induced by testosterone propionate

51.裸鼠人前列腺癌药效学试验
Pharmacodynamic test of the nude mice model bearing with the prostate cancer

52.AHP抗前列腺增生药物临床前开发研究
Preclinical development study on AHP against prostatic hyperplasia

53.ED 010523壮阳药效学研究
Pharmacodynamic study on the Strengthening Yang action of ED 010523

54.中药泉宁治疗前列腺增生的药理研究
Pharmacological research on Chinese Herbs Quanning for the treatment of benin prostatic hyperplasia

55.男性抗生育化合物及杀精子化合物筛选研
Screening studies on the compounds of male anti-fertility and the compounds of killing sperm

56、ED1浸膏对去势大鼠的壮阳作用
Strengthening Yang action of ED1 extract in ovariectomized rats

57、寻找诊断新西兰兔早早孕金指标的研究
Study on diagnostic golden index of New Zealand rabbits in early pergnancy

58、消避灵阴道栓家兔体内外抗微生物试验
Anti-microbial tests of Xiaobiling pessary in rabbits in vivo and in vitro

59、消避灵阴道栓抗大鼠生育以及体内杀精子试验
Experiments of antifertility effect of Xiaobiling pessary in rats and killing sperm action in vivo

60、消避灵阴道栓抗家兔生育以及体内杀精子试验
Experiments of antifertility effect of Xiaobiling pessary in rabbits and killing sperm action in vivo

61、Y005药物治疗子宫内膜异位症的药效学研究
Pharmacodynamic study on the treatment of endometriosis of Y005

62、中药子宫肌瘤浸膏治疗“大鼠子宫肌瘤模型”的实验观察
Experimental observation on the treatment of uterine myoma in rats of Chinese Herbs Uterine Myoma extraction

63、中药子宫肌瘤浸膏治疗“豚鼠子宫肌瘤模型”的实验观察
Experimental observation on the treatment of uterine myoma in guinea pigs of Chinese Herbs Uterine Myoma extraction

64、中药内异浸膏治疗“家兔（或豚鼠）内异症模型”的实验观察
Experimental observation on the treatment of endometriosis in rabbits(or guinea pigs) of Chinese Herbs Endometriosis extraction

65、新颖的孕激素微球制剂对子宫内膜异位症的作用机制研究
Study on the mechanism of the treatment of endometriosis of new progestogen microspheres

66、新生血管抑制剂筛选以及对子宫内膜的作用
Establishment of screening for angiogenesis inhibitors and its effects on the endometrium

67、中药红藤颗粒剂治疗“大鼠子宫内异症模型”的实验观察
Experimental observation on the treatment of endometriosis in rats of Chinese Herbs Sargentgloryvine Stem granules

68、中药红藤颗粒剂治疗“家兔子宫内异症模型”的实验观察
Experimental observation on the treatment of endometriosis in rabbits of Chinese Herbs Sargentgloryvine Stem granules

69、孕三烯酮阴道环的避孕药效学研究
Pharmacodynamic study on contraception of gestrinone vaginal ring

70、孕三烯酮阴道环的血浓度研究
The study of gestrinone serum concentration administrating with gestrinone vaginal ring

71、左炔诺孕酮（LNG）口崩片给药后血样中LNG含量的测定
Determination of LNG content in blood following administration of LNG

72、固定式宫内节育器中的吲哚美辛含量测试
Determination of indomethacin content in fixed IUD

73.3#-BETA和4#-G雌激素或抗雌激素样作用研究
Study on the estrogenic effects or anti-estrogenic effects of 3#-BETA and 4#-G

74.二仙汤胶囊的性激素药效研究
Pharmacodynamic study on the effects of Er-Xian decoction on sex hormone

75.甲地孕酮硅橡胶避孕环药效学试验
Pharmacodynamic tests of megestrol acetate silicon rubber contraceptive vaginal ring