研究项目（三）study projects-3

二、其他药理学研究
Other Pharmacology

1、抗凝药物（SAR-系列）筛选药效学试验
Pharmacodynamic experiment of screening anticoagulant drugs (SAR-series)

2、抗凝系列药物筛选药效学试验
Pharmacodynamic experiment of screening anticoagulant drugs

3、抗凝药物（SAR-9）筛选药效学试验
Pharmacodynamic experiment of screening anticoagulant drugs (SAR-9)

4、急（慢）性肾功能衰竭大鼠模型的建立及系列化合物治疗效果的研究
Study on the establishment of models of acute(chronic) renal failure in rats and therapy of series compounds

5、复方法莫替丁对抗大鼠胃溃疡药效学研究
Pharmacodynamic study on anti-gastric ulcer action of compoun famotidine

6、局部麻醉药药效筛选试验
Pharmacodynamic experiment of screening local anesthetics

7、肠道新药评价模型的建立及AWA药效学验证试验
Establishment of evaluation model on intestinal new drug and AWA pharmacodynamics verifying test

8、重组r干扰素体外抗鼻病毒药效学试验及鼻黏膜刺激试验
Pharmacodynamic experiment of anti-rhinovirus action of IFNr and nasal mucosa irritation test

9、凯金皇室洗液抗微生物药效学研究
Pharmacodynamic study on antimicrobial action of Kaijing royal lotion

10、转入Pro-UK基因的小鼠骨髓瘤细胞株（SP20）染色体稳定性检定
Stability test of chromosome of mouse myeloma cell line (SP20) transferred Pro-UK gene

11、抗感冒喷剂与治疗作用有关的主要药效学试验
Primary pharmacodynamic test of effect of anti-cold spray

12、消毒水Det 1323和Det 2313性能测试
Performance test of disinfect solution Det 1323 and Det 2313

13、脑宁对卒中型自发性高血压大鼠的影响
Effect of Naoning on SHRsp rats

第三部分：毒理学研究（包括：新药安全性评价）
3. TOXICOLOGICAL STUDIES(Including Safety Evaluation of New Drugs)

一、一般药理研究
General Pharmacological study

1.利用ICR小鼠进行的研究
Study with ICR mice

(1)CT-1139小鼠灌胃一般药理学试验
General pharmacology of CT-1139 by intragastric administration in ICR mice

(2)复方坦洛新非那雄胺小鼠灌胃一般药理学试验
General pharmacology of Compound tamsolusin and finasteride by intragastric administration in ICR mice

(3)雄地那非小鼠灌胃一般药理学试验
General pharmacology of Xiongdinafei by intragastric administration in ICR mice

(4)注射用重组人促卵泡激素小鼠皮下注射一般药理学试验
General pharmacology of rhFSH injection by subcutaneous injection in ICR mice

(5)NCP4小鼠静脉注射一般药理学试验
General pharmacology of NCP4 by intravenous administration in ICR mice

(6)YF-49-92.MLS 小鼠灌胃一般药理学试验
General pharmacology of YF-49-92.MLS by intragastric administration in ICR mice

(7)乌骨藤总苷小鼠灌胃一般药理学试验
General pharmacology of the total glycosides of Marsdenia tenaccima by intragastric administration in ICR mice

(8)龙胆总苷小鼠灌胃一般药理学试验
General pharmacology of the total glycosides of Radix Gentianae by intragastric administration in ICR mice

(9)注射用灯盏花素小鼠静脉给药一般药理学试验
General pharmacological study on erigeron injection by intravenous administration in mice

(10)注射用头孢他美钠小鼠静脉给药（iv）一般药理学试验
General pharmacological study on cefetamet sodium injection by intravenous administration in mice

(11)左旋泮托拉唑钠ICR小鼠静脉注射（iv）一般药理学试验
General pharmacological study on (L)-pantoprazole sodium injection by intravenous injection in ICR mice

(12)聚乙二醇化重组人干扰素α-2b ICR小鼠皮下注射（sc）一般药理学试验
General pharmacological study on PEG-IFN-α-2b by subcutaneous injection in ICR mice

(13)消避灵阴道栓ICR小鼠阴道给药一般药理学试验
General pharmacological study on Xiaobiling pessary by vaginal injection in ICR mice

(14)多西他赛脂质体ICR小鼠静脉注射（iv）一般药理学试验
General pharmacological study on docetaxel liposomes by intravenous injection in ICR mice

(15)HGH ICR小鼠皮下注射（sc）一般药理学试验
General pharmacological study on HGH by subcutaneous injection in ICR mice

(16)重组抗CD20人鼠嵌合单克隆抗体ICR小鼠静脉注射（iv）一般药理学试验
General pharmacological study on recombinant human/mouse chimeric anti-CD20 monoclonal antibody by intravenous injection in ICR mice

(17)聚乙二醇重组人生长激素ICR小鼠皮下注射（sc）一般药理学试验
General pharmacological study on PEG- rhGH by subcutaneous injection in ICR mice

(18)重组抗CD3人鼠嵌合单克隆抗体ICR小鼠静脉注射（iv）一般药理学试验
General pharmacological study on recombinant human/mouse chimeric anti-CD3 monoclonal antibody by intravenous injection in ICR mice

(19)注射用脉络宁ICR小鼠静脉注射（iv）一般药理学试验
General pharmacological study on Mailuoning injection by intravenous injection in ICR mice

(20)重组抗EGFR人鼠嵌合单克隆抗体ICR小鼠静脉注射（iv）一般药理学试验
General pharmacological study on recombinant human/mouse chimeric anti-EGFR monoclonal antibody by intravenous injection in ICR mice

(21)重组SM-FL双功能抗体ICR小鼠静脉注射（iv）一般药理学试验
General pharmacological study on recombinant SM-FL bispecific antibody by intravenous injection in ICR mice

(22)重组抗Ig E人源化单克隆抗体ICR小鼠静脉注射（iv）一般药理学试验
General pharmacological study on recombinant anti-IgE humanized monoclonal antibody by intravenous injection in ICR mice

(23)注射用冠心灵ICR小鼠静脉注射（iv）一般药理学试验
General pharmacological study on Guanxinning injection by intravenous injection in ICR mice

(24)注射用丹红ICR小鼠静脉注射（iv）一般药理学试验
General pharmacological study on Danhong injection by intravenous injection in ICR mice

(25)重组抗CD52人源化单克隆抗体ICR小鼠静脉注射（iv）一般药理学试验
General pharmacological study on recombinant anti-CD52 humanized monoclonal antibody by intravenous injection in ICR mice

(26)重组抗TNF人鼠嵌合化单克隆抗体ICR小鼠静脉注射（iv） 一般药理学试验
General pharmacological study on recombinant human/mouse chimeric anti-TNF monoclonal antibody by intravenous injection in ICR mice

(27)重组抗CD25人鼠嵌合化单克隆抗体ICR小鼠静脉注射（iv）一般药理学试验
General pharmacological study on recombinant anti-CD25 humanized monoclonal antibody by intravenous injection in ICR mice

(28)聚乙二醇化天花粉蛋白ICR小鼠静脉注射（iv）一般药理学试验
General pharmacological study on PEG-trichosanthin by intravenous injection in ICR mice

(29)长效孕三烯酮微球注射剂ICR小鼠皮下注射（sc） 一般药理学试验
General pharmacological study on long-acting gestrinone microspheres injection by subcutaneous injection in ICR mice

(30)AWA静脉注射液ICR小鼠静脉注射（iv）一般药理学试验
General pharmacological study on AWA injection by intravenous injection in ICR mice

(31)阿地福韦双特戊酰氧基甲酯SD大鼠灌胃（ig）一般药理学试验
General pharmacological study on adefovir dipivixil by intragastric administration in SD rats

(32)阿德福韦酯ICR小鼠灌胃（ig）一般药理学试验
General pharmacological study on adefovir dipivixil by intragastric administration in ICR mice

(33)枸缘酸舍曲林ICR小鼠灌胃（ig）一般药理学试验
General pharmacological study on sertraline citrate by intragastric administration in ICR mice

2.利用Beagle犬进行的研究
Study with beagle dogs

(1)CT-1139 Beagle犬灌胃一般药理学试验
General pharmacology of CT-1139 by intragastric administration in beagle dogs

(2)复方坦洛新非那雄胺Beagle犬灌胃一般药理学试验
General pharmacology of Compound tamsolusin and finasteride by intragastric administration in beagle dogs

(3)雄地那非Beagle犬灌胃一般药理学试验
General pharmacology of Xiongdinafei by intragastric administration in beagle dogs

(4)NCP4 Beagle犬静脉滴注一般药理学试验
General pharmacology of NCP4 by intravenous drip in beagle dogs

(5)YF-49-92.MLS Beagle犬灌胃一般药理学试验
General pharmacology of YF-49-92.MLS by intragastric administration in beagle dogs

(6)乌骨藤总苷Beagle犬灌胃一般药理学试验
General pharmacology of the total glycosides of Marsdenia tenaccima by intragastric administration in beagle dogs

(7)龙胆总苷Beagle犬一般药理学试验
General pharmacology of the total glycosides of Radix Gentianae by intragastric administration in beagle dogs

(8)注射用灯盏花素Beagle犬静脉滴注一般药理学试验
General pharmacological study on erigeron injection by intravenous drip in beagle dogs

(9)注射用头孢他美钠Beagle犬静脉给药（iv）一般药理学试验
General pharmacological study on cefetamet sodium injection by intravenous administration in beagle dogs

(10)左旋泮托拉唑钠Beagle犬静脉注射（iv）一般药理学试验
General pharmacological study on (L)-pantoprazole sodium injection by intravenous injection in beagle dogs

(11)消避灵阴道栓Beagle犬阴道给药一般药理学试验
General pharmacological study on Xiaobiling pessary by vaginal injection in beagle dogs

(12)多西他赛脂质体Beagle犬静脉注射（iv）一般药理学试验
General pharmacological study on docetaxel liposomes by intravenous injection in beagle dogs

(13)注射用黄豆苷元Beagle犬静脉注射（iv）一般药理学试验
General pharmacological study on daidzein injection by intravenous injection in beagle dogs

(14)注射用脉络宁Beagle犬静脉注射（iv）一般药理学试验
General pharmacological study on Mailuoning injection by intravenous injection in beagle dogs

(15)注射用冠心灵Beagle犬静脉注射（iv）一般药理学试验
General pharmacological study on Guanxinning injection by intravenous injection in beagle dogs

(16)注射用丹红Beagle犬静脉注射（iv）一般药理学试验
General pharmacological study on Danhong injection by intravenous injection in beagle dogs

(17)聚乙二醇化天花粉蛋白Beagle犬静脉注射（iv）一般药理试验
General pharmacological study on PEG-trichosanthin by intravenous injection in beagle dogs

(18)长效孕三烯酮微球注射剂Beagle犬皮下注射（sc）一般药理学试验
General pharmacological study on long-acting gestrinone microspheres injection by subcutaneous injection in beagle dogs

(19)AWA静脉注射液Beagle犬静脉注射（iv）一般药理学试验
General pharmacological study on AWA injection by intravenous injection in beagle dogs

(20)阿地福韦双特戊酰氧基甲酯Beagle犬灌胃（ig）一般药理学试验
General pharmacological study on adefovir dipivixil by intragastric administration in beagle dogs

(21)阿德福韦酯Beagle犬灌胃（ig）一般药理学试验
General pharmacological study on adefovir dipivixil by intragastric administration in beagle dogs

(22)枸缘酸舍曲林Beagle犬灌胃（ig）一般药理学试验
General pharmacological study on sertraline citrate by intragastric administration in beagle dogs